Anti-ABCC6 antibody (290-370) (STJ190991)

SKU:
STJ190991

Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Rat, Mouse
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody anti-Atp-Binding Cassette Sub-Family C Member 6 (290-370) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCC6
Gene ID: 368
Uniprot ID: MRP6_HUMAN
Immunogen Region: 290-370
Specificity: ABCC6 polyclonal antibody (Atp-Binding Cassette Sub-Family C Member 6) binds to endogenous Atp-Binding Cassette Sub-Family C Member 6 at the amino acid region 290-370.
Immunogen: Synthesized peptide derived from human protein at aa range 290-370
Post Translational Modifications Glycosylated.
Function Isoform 1: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin. Isoform 1: Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases.
Protein Name Atp-Binding Cassette Sub-Family C Member 6
Anthracycline Resistance-Associated Protein
Multi-Specific Organic Anion Transporter E
Moat-E
Multidrug Resistance-Associated Protein 6
Database Links Reactome: R-HSA-382556
Reactome: R-HSA-5690338
Cellular Localisation Isoform 1: Basolateral Cell Membrane
Multi-Pass Membrane Protein
Isoform 2: Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family C Member 6 antibody
Anti-Anthracycline Resistance-Associated Protein antibody
Anti-Multi-Specific Organic Anion Transporter E antibody
Anti-Moat-E antibody
Anti-Multidrug Resistance-Associated Protein 6 antibody
Anti-ABCC6 antibody
Anti-ARA antibody
Anti-MRP6 antibody

Information sourced from Uniprot.org

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