| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Multidrug resistance-associated protein 1 transporter (110-190 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABCC1 |
| Gene ID: |
4363 |
| Uniprot ID: |
MRP1_HUMAN |
| Immunogen Region: |
110-190 aa |
| Specificity: |
MRP1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 110-190 |
| Function | Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells. Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export. Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway. |
| Protein Name | Multidrug Resistance-Associated Protein 1Atp-Binding Cassette Sub-Family C Member 1Glutathione-S-Conjugate-Translocating Atpase Abcc1Leukotriene C(4 TransporterLtc4 Transporter |
| Database Links | Reactome: R-HSA-189483Reactome: R-HSA-2142691Reactome: R-HSA-382556Reactome: R-HSA-9707564Reactome: R-HSA-9753281Reactome: R-HSA-9758890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Multidrug Resistance-Associated Protein 1 antibodyAnti-Atp-Binding Cassette Sub-Family C Member 1 antibodyAnti-Glutathione-S-Conjugate-Translocating Atpase Abcc1 antibodyAnti-Leukotriene C(4 Transporter antibodyAnti-Ltc4 Transporter antibodyAnti-ABCC1 antibodyAnti-MRP antibodyAnti-MRP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
