Anti-ABCB4 antibody (20-100) (STJ190988)


Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Rat, Mouse
Short Description: Rabbit polyclonal antibody anti-Phosphatidylcholine Translocator Abcb4 (20-100) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCB4
Gene ID: 5244
Uniprot ID: MDR3_HUMAN
Immunogen Region: 20-100
Specificity: ABCB4 polyclonal antibody (Phosphatidylcholine Translocator Abcb4) binds to endogenous Phosphatidylcholine Translocator Abcb4 at the amino acid region 20-100.
Immunogen: Synthesized peptide derived from human protein at aa range 20-100
Function Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes. Required for proper phospholipid bile formation. Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner. Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane. In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts. Does not confer multidrug resistance.
Protein Name Phosphatidylcholine Translocator Abcb4
Atp-Binding Cassette Sub-Family B Member 4
Multidrug Resistance Protein 3
P-Glycoprotein 3
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-382556
Reactome: R-HSA-5678771
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Membrane Raft
Cytoplasmic Vesicle
Clathrin-Coated Vesicle
Localized At The Apical Canalicular Membrane Of The Epithelial Cells Lining The Lumen Of The Bile Canaliculi And Biliary Ductules
Transported From The Golgi To The Apical Bile Canalicular Membrane In A Rack1-Dependent Manner
Redistributed Into Pseudocanaliculi Formed Between Cells In A Bezafibrate- Or Ppara-Dependent Manner
Localized Preferentially In Lipid Nonraft Domains Of Canalicular Plasma Membranes
Alternative Antibody Names Anti-Phosphatidylcholine Translocator Abcb4 antibody
Anti-Atp-Binding Cassette Sub-Family B Member 4 antibody
Anti-Multidrug Resistance Protein 3 antibody
Anti-P-Glycoprotein 3 antibody
Anti-ABCB4 antibody
Anti-MDR3 antibody
Anti-PGY3 antibody

Information sourced from

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