| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-P Glycoprotein (590-689) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABCB1 |
| Gene ID: |
5243 |
| Uniprot ID: |
MDR1_HUMAN |
| Immunogen Region: |
590-689 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 590-689 of human P Glycoprotein (NP_000918.2). |
| Immunogen Sequence: |
STVRNADVIAGFDDGVIVEK GNHDELMKEKGIYFKLVTMQ TAGNEVELENAADESKSEID ALEMSSNDSRSSLIRKRSTR RSVRGSQAQDRKLSTKEALD |
| Tissue Specificity | Expressed in small intestine. Expressed in liver, kidney and brain. |
| Function | Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. |
| Protein Name | Atp-Dependent Translocase Abcb1Atp-Binding Cassette Sub-Family B Member 1Multidrug Resistance Protein 1P-Glycoprotein 1Phospholipid Transporter Abcb1Cd Antigen Cd243 |
| Database Links | Reactome: R-HSA-2161517Reactome: R-HSA-382556Reactome: R-HSA-9754706Reactome: R-HSA-9757110 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneCytoplasmAbcb1 Localization Is Influenced By C1orf115 Expression Levels (Plasma Membrane Versus Cytoplasm)Localized To The Apical Membrane Of Enterocytes |
| Alternative Antibody Names | Anti-Atp-Dependent Translocase Abcb1 antibodyAnti-Atp-Binding Cassette Sub-Family B Member 1 antibodyAnti-Multidrug Resistance Protein 1 antibodyAnti-P-Glycoprotein 1 antibodyAnti-Phospholipid Transporter Abcb1 antibodyAnti-Cd Antigen Cd243 antibodyAnti-ABCB1 antibodyAnti-MDR1 antibodyAnti-PGY1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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