Anti-ABCA4 antibody (630-710) (STJ191313)

SKU:
STJ191313

Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Mouse
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody anti-Retinal-Specific Phospholipid-Transporting Atpase Abca4 (630-710) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCA4
Gene ID: 24
Uniprot ID: ABCA4_HUMAN
Immunogen Region: 630-710
Specificity: ABCA4 polyclonal antibody (Retinal-Specific Phospholipid-Transporting Atpase Abca4) binds to endogenous Retinal-Specific Phospholipid-Transporting Atpase Abca4 at the amino acid region 630-710.
Immunogen: Synthesized peptide derived from human protein at aa range 630-710
Post Translational Modifications Proteolytic cleavage by trypsin leads to a 120-kDa N-terminal fragment and a 115-kDa C-terminal fragment that are linked through disulfide bonds. N-glycosylated. Phosphorylation is independent of light exposure and modulates ATPase activity.
Function Flippase that catalyzes in an ATP-dependent manner the transport of retinal-phosphatidylethanolamine conjugates like the 11-cis and all-trans isomers of N-retinylidene-phosphatidylethanolamine from the lumen to the cytoplasmic leaflet of photoreceptor outer segment disk membranes, where N-cis-retinylidene-phosphatidylethanolamine (N-cis-R-PE) is then isomerized to its all-trans isomer (N-trans-R-PE) and reduced by RDH8 to produce all-trans-retinol (all-trans-rol) and therefore prevents the accumulation of excess of 11-cis-retinal and its schiff-base conjugate and the formation of toxic bisretinoid. May display both ATPase and GTPase activity that is strongly influenced by the lipid environment and the presence of retinoid compounds. Binds the unprotonated form of N-retinylidene-phosphatidylethanolamine with high affinity in the absence of ATP, and ATP binding and hydrolysis induce a protein conformational change that causes the dissociation of N-retinylidene-phosphatidylethanolamine.
Protein Name Retinal-Specific Phospholipid-Transporting Atpase Abca4
Atp-Binding Cassette Sub-Family A Member 4
Rim Abc Transporter
Rim Proteinv
Rmp
Retinal-Specific Atp-Binding Cassette Transporter
Stargardt Disease Protein
Database Links Reactome: R-HSA-2453864
Reactome: R-HSA-2453902
Reactome: R-HSA-382556
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum
Cytoplasmic Vesicle
Cell Projection
Cilium
Photoreceptor Outer Segment
Localized To The Rim And Incisures Of Rod Outer Segments Disks
Alternative Antibody Names Anti-Retinal-Specific Phospholipid-Transporting Atpase Abca4 antibody
Anti-Atp-Binding Cassette Sub-Family A Member 4 antibody
Anti-Rim Abc Transporter antibody
Anti-Rim Proteinv antibody
Anti-Rmp antibody
Anti-Retinal-Specific Atp-Binding Cassette Transporter antibody
Anti-Stargardt Disease Protein antibody
Anti-ABCA4 antibody
Anti-ABCR antibody

Information sourced from Uniprot.org

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