Anti-ABCA3 antibody (450-530aa) (STJ190577)

SKU:
STJ190577

Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Mouse
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody Anti-Phospholipid-transporting ATPase (450-530aa) is suitable for use in Western Blot and ELISA.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Purification: ABCA3 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
Concentration: 1 mg/ml
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCA3
Gene ID: 21
Uniprot ID: ABCA3_HUMAN
Immunogen Region: 450-530aa
Specificity: ABCA3 polyclonal antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from human ABCA3 protein.
Post Translational Modifications N-glycosylated. Localization at intracellular vesicles is accompanied by processing of oligosaccharide from high mannose type to complex type. N-linked glycosylation at Asn-124 and Asn-140 is required for stability and efficient anterograde trafficking and prevents from proteasomal degradation. Proteolytically cleaved by CTSL and to a lower extent by CTSB within multivesicular bodies (MVB) and lamellar bodies (LB) leading to a mature form of 150 kDa.
Function Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant. Transports preferentially phosphatidylcholine containing short acyl chains. In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity.
Protein Name Phospholipid-Transporting Atpase Abca3
Abc-C Transporter
Atp-Binding Cassette Sub-Family A Member 3
Atp-Binding Cassette Transporter 3
Atp-Binding Cassette 3
Xenobiotic-Transporting Atpase Abca3 Cleaved Into - 150 Kda Mature Form
Database Links Reactome: R-HSA-1369062
Reactome: R-HSA-5683678
Reactome: R-HSA-5683826
Reactome: R-HSA-5688399
Cellular Localisation Endosome
Multivesicular Body Membrane
Multi-Pass Membrane Protein
Cytoplasmic Vesicle Membrane
Late Endosome Membrane
Lysosome Membrane
Localized In The Limiting Membrane Of Lamellar Bodies In Lung Alveolar Type Ii Cells
Trafficks Via The Golgi
Sorting Vesicles (Svs) And Late Endosome/Multivesicular Body Network Directly To The Outer Membrane Of Lamellar Bodies In At2 Lung Epithelial Cells Or To Lysosomes And Lysosomal-Related Organelles (Lros) In Other Cells Where Undergoes Proteolytic Cleveage And Oligosaccharide Processing From High Mannose Type To Complex Type
Oligomers Formation Takes Place In A Post-Endoplasmic Reticulum Compartment
Alternative Antibody Names Anti-Phospholipid-Transporting Atpase Abca3 antibody
Anti-Abc-C Transporter antibody
Anti-Atp-Binding Cassette Sub-Family A Member 3 antibody
Anti-Atp-Binding Cassette Transporter 3 antibody
Anti-Atp-Binding Cassette 3 antibody
Anti-Xenobiotic-Transporting Atpase Abca3 Cleaved Into - 150 Kda Mature Form antibody
Anti-ABCA3 antibody
Anti-ABC3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance