| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AANAT (1-207) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AANAT |
| Gene ID: |
15 |
| Uniprot ID: |
SNAT_HUMAN |
| Immunogen Region: |
1-207 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human AANAT (NP_001079.1). |
| Immunogen Sequence: |
MSTQSTHPLKPEAPRLPPGI PESPSCQRRHTLPASEFRCL TPEDAVSAFEIEREAFISVL GVCPLYLDEIRHFLTLCPEL SLGWFEEGCLVAFIIGSLWD KERLMQESLTLHRSGGHIAH LHVLAVHRAFRQQGRGPILL WRYLHHLGSQPAVRRAALMC EDALVPFYERFSFHAVGPCA ITVGSLTFMELHCSLRGHPF LRRNSGC |
| Tissue Specificity | Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland. |
| Post Translational Modifications | cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins. |
| Function | Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. |
| Protein Name | Serotonin N-AcetyltransferaseSerotonin AcetylaseAralkylamine N-AcetyltransferaseAa-Nat |
| Database Links | Reactome: R-HSA-209931 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serotonin N-Acetyltransferase antibodyAnti-Serotonin Acetylase antibodyAnti-Aralkylamine N-Acetyltransferase antibodyAnti-Aa-Nat antibodyAnti-AANAT antibodyAnti-SNAT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
