||WB, IHC-P, IF-P, ELISA
||Mouse, Rat, Monkey
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-EIF4EBP1 (10-90) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
||PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
||The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
||WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000
||Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
||4E-BP1 polyclonal antibody (EIF4EBP1) binds to endogenous EIF4EBP1 at the amino acid region 10-90.
||The antiserum was produced against synthesized peptide derived from mouse 4E-BP1 at amino acid range 35-84
| Function || Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. |
| Protein Name || Eukaryotic Translation Initiation Factor 4e-Binding Protein 14e-Bp1Eif4e-Binding Protein 1Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1Phas-I |
| Database Links || Reactome: R-HSA-166208Reactome: R-HSA-72662 |
| Alternative Antibody Names || Anti-Eukaryotic Translation Initiation Factor 4e-Binding Protein 1 antibodyAnti-4e-Bp1 antibodyAnti-Eif4e-Binding Protein 1 antibodyAnti-Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1 antibodyAnti-Phas-I antibodyAnti-EIF4EBP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance