||Pep-ELISA, WB, IHC
||Human, Mouse, Rat, Dog, Pig
||Goat polyclonal anti-14-3-3 sigma/Stratifin antibody is suitable for use in ELISA, Western Blot and Immunohistochemistry.
||FOR RESEARCH USE ONLY (RUO).
||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Aliquot and store at-20°C. Minimize freezing and thawing.
||Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
||Store at-20°C and avoid freeze-thaw cycles.
||WB-0.03-0.1µg/mlIHC-Recommended concentration, 2-4µg/mlELISA-antibody detection limit dilution 1:16000.
| Post Translational Modifications || Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation. |
| Function || Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. |
| Protein Name || 14-3-3 Protein SigmaStratifin |
| Database Links || Reactome: R-MMU-111447Reactome: -MMU-5625740Reactome: -MMU-5628897Reactome: -MMU-6804114Reactome: -MMU-75035Reactome: -MMU-9614399 |
| Cellular Localisation || CytoplasmNucleusSecretedMay Be Secreted By A Non-Classical Secretory Pathway |
| Alternative Antibody Names || Anti-14-3-3 Protein Sigma antibodyAnti-Stratifin antibodyAnti-Sfn antibodyAnti-Mkrn3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance