| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-14-3-3 alpha/beta (147-246) is suitable for use in Western Blot research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S0MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | YWHAB |
| Gene ID: | 7529 |
| Uniprot ID: | 1433B_HUMAN |
| Immunogen Region: | 147-246 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 147-246 of human 14-3-3 alpha/beta (P31946). |
| Immunogen Sequence: | SQQAYQEAFEISKKEMQPTH PIRLGLALNFSVFYYEILNS PEKACSLAKTAFDEAIAELD TLNEESYKDSTLIMQLLRDN LTLWTSENQGDEGDAGEGEN |
| Post Translational Modifications | The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. |
| Function | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. |
| Protein Name | 14-3-3 Protein Beta/AlphaProtein 1054Protein Kinase C Inhibitor Protein 1Kcip-1 Cleaved Into - 14-3-3 Protein Beta/Alpha - N-Terminally Processed |
| Database Links | Reactome: R-HSA-111447Reactome: R-HSA-1445148Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-170968Reactome: R-HSA-170984Reactome: R-HSA-2028269Reactome: R-HSA-392517Reactome: R-HSA-450385Reactome: R-HSA-450513Reactome: R-HSA-5625740Reactome: R-HSA-5628897Reactome: R-HSA-5673000Reactome: R-HSA-5674135Reactome: R-HSA-5675221Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-75035Reactome: R-HSA-9614399Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9726840Reactome: R-HSA-9726842Reactome: R-HSA-9735871Reactome: R-HSA-9755779 |
| Cellular Localisation | CytoplasmMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvVacuole Membrane(Microbial Infection) Upon Infection With Chlamydia TrachomatisThis Protein Is Associated With The Pathogen-Containing Vacuole Membrane Where It Colocalizes With Incg |
| Alternative Antibody Names | Anti-14-3-3 Protein Beta/Alpha antibodyAnti-Protein 1054 antibodyAnti-Protein Kinase C Inhibitor Protein 1 antibodyAnti-Kcip-1 Cleaved Into - 14-3-3 Protein Beta/Alpha - N-Terminally Processed antibodyAnti-YWHAB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
