Androgen Receptor protein (STJ505894)


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Applications: WB
Short Description: Androgen Receptor-protein if for use in research applications.
Concentration: The concentration of the sample is empirically set so that 20 Mu l per lane in Western and blotted with corresponding affinity purified antibody will give a clean band with a high signal to noise ratio on the gel.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: AR
Gene ID: 367
Post Translational Modifications Sumoylated on Lys-388 (major) and Lys-521. Ubiquitinated. Deubiquitinated by USP26. 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity. Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-535 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression. Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity and may be responsible for androgen-independent progression of prostate cancer. Phosphorylation at Ser-83 by CDK9 regulates AR promoter selectivity and cell growth. Phosphorylation by PAK6 leads to AR-mediated transcription inhibition. Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.
Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Isoform 3: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. Isoform 4: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones.
Protein Name Androgen Receptor
Dihydrotestosterone Receptor
Nuclear Receptor Subfamily 3 Group C Member 4
Database Links Reactome: R-HSA-3371497
Reactome: R-HSA-383280
Reactome: R-HSA-4090294
Reactome: R-HSA-5625886
Reactome: R-HSA-5689880
Reactome: R-HSA-8940973
Cellular Localisation Nucleus
Detected At The Promoter Of Target Genes
Predominantly Cytoplasmic In Unligated Form But Translocates To The Nucleus Upon Ligand-Binding
Can Also Translocate To The Nucleus In Unligated Form In The Presence Of Rack1
Alternative Antibody Names Anti-Androgen Receptor antibody
Anti-Dihydrotestosterone Receptor antibody
Anti-Nuclear Receptor Subfamily 3 Group C Member 4 antibody
Anti-AR antibody
Anti-DHTR antibody
Anti-NR3C4 antibody

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