| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
ADA Positive Control for STJ506025 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
ADA |
| Gene ID: |
100 |
| Uniprot ID: |
ADA_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with ADA antibody STJ506025. |
| Immunogen: |
Purified Adenosine Deaminase/Adenosine Aminohydrolase. |
| Tissue Specificity | Found in all tissues, occurs in large amounts in T-lymphocytes. Expressed at the time of weaning in gastrointestinal tissues. |
| Function | Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion. Enhances CD4+ T-cell differentiation and proliferation. Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change. Stimulates plasminogen activation. Plays a role in male fertility. Plays a protective role in early postimplantation embryonic development. |
| Peptide Name | Adenosine DeaminaseAdenosine Aminohydrolase |
| Database Links | Reactome: R-HSA-74217Reactome: R-HSA-9734735Reactome: R-HSA-9755088 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinExtracellular SideCell JunctionCytoplasmic Vesicle LumenCytoplasmLysosomeColocalized With Dpp4 At The Cell Surface |
| Alternative Peptide Names | Adenosine Deaminase proteinAdenosine Aminohydrolase proteinADA proteinADA1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
