ADA Blocking Peptide for STJ506023 peptide (STJ505780)

Tissue Specificity	Found in all tissues, occurs in large amounts in T-lymphocytes. Expressed at the time of weaning in gastrointestinal tissues.
Function	Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion. Enhances CD4+ T-cell differentiation and proliferation. Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change. Stimulates plasminogen activation. Plays a role in male fertility. Plays a protective role in early postimplantation embryonic development.
Peptide Name	Adenosine Deaminase Adenosine Aminohydrolase
Database Links	Reactome: R-HSA-74217 Reactome: R-HSA-9734735 Reactome: R-HSA-9755088
Cellular Localisation	Cell Membrane Peripheral Membrane Protein Extracellular Side Cell Junction Cytoplasmic Vesicle Lumen Cytoplasm Lysosome Colocalized With Dpp4 At The Cell Surface
Alternative Peptide Names	Adenosine Deaminase protein Adenosine Aminohydrolase protein ADA protein ADA1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance