| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
5HT2C Receptor Blocking Peptide is synthetically produced from the 400-458 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
HTR2C |
| Gene ID: |
3358 |
| Uniprot ID: |
5HT2C_HUMAN |
| Immunogen Region: |
400-458 |
| Immunogen: |
Synthetic peptide taken within amino acid region 400-458 on human 5-hydroxytryptamine receptor 2C. |
| Tissue Specificity | Detected in brain. |
| Post Translational Modifications | N-glycosylated. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis. |
| Peptide Name | 5-Hydroxytryptamine Receptor 2c5-Ht-2c5-Ht2c5-Htr2c5-Hydroxytryptamine Receptor 1c5-Ht-1c5-Ht1cSerotonin Receptor 2c |
| Database Links | Reactome: R-HSA-390666Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | 5-Hydroxytryptamine Receptor 2c protein5-Ht-2c protein5-Ht2c protein5-Htr2c protein5-Hydroxytryptamine Receptor 1c protein5-Ht-1c protein5-Ht1c proteinSerotonin Receptor 2c proteinHTR2C proteinHTR1C protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
